| # | Major League Soccer | G | W | D | L | GF | GA | Pts | +- | ||
| # | Eastern Conference | G | W | D | L | GF | GA | Pts | +- | ||
| - | New York Red Bulls | 34 | 22 | 5 | 7 | 62 | 33 | 71 | 29 | ||
| - | Atlanta United FC | 34 | 21 | 6 | 7 | 70 | 44 | 69 | 26 | Champions | |
| - | New York City FC | 34 | 16 | 8 | 10 | 59 | 45 | 56 | 14 | ||
| - | DC United | 34 | 14 | 9 | 11 | 60 | 50 | 51 | 10 | ||
| - | Columbus Crew | 34 | 14 | 9 | 11 | 43 | 45 | 51 | -2 | ||
| - | Philadelphia Union | 34 | 15 | 5 | 14 | 49 | 50 | 50 | -1 | ||
| - | Montréal Impact | 34 | 14 | 4 | 16 | 47 | 53 | 46 | -6 | ||
| - | New England Revolution | 34 | 10 | 11 | 13 | 49 | 55 | 41 | -6 | ||
| - | Toronto FC | 34 | 10 | 6 | 18 | 59 | 64 | 36 | -5 | ||
| - | Chicago Fire | 34 | 8 | 8 | 18 | 48 | 61 | 32 | -13 | ||
| - | Orlando City SC | 34 | 8 | 4 | 22 | 43 | 74 | 28 | -31 | ||
| # | Western Conference | G | W | D | L | GF | GA | Pts | +- | ||
| - | Sporting Kansas City | 34 | 18 | 8 | 8 | 65 | 40 | 62 | 25 | ||
| - | Seattle Sounders FC | 34 | 18 | 5 | 11 | 52 | 37 | 59 | 15 | ||
| - | Los Angeles FC | 34 | 16 | 9 | 9 | 68 | 52 | 57 | 16 | ||
| - | FC Dallas | 34 | 16 | 9 | 9 | 52 | 44 | 57 | 8 | ||
| - | Portland Timbers | 34 | 15 | 9 | 10 | 54 | 48 | 54 | 6 | ||
| - | Real Salt Lake | 34 | 14 | 7 | 13 | 55 | 58 | 49 | -3 | ||
| - | Los Angeles Galaxy | 34 | 13 | 9 | 12 | 66 | 64 | 48 | 2 | ||
| - | Vancouver Whitecaps | 34 | 13 | 8 | 13 | 54 | 67 | 47 | -13 | ||
| - | Houston Dynamo | 34 | 10 | 8 | 16 | 58 | 58 | 38 | 0 | ||
| - | Minnesota United FC | 34 | 11 | 3 | 20 | 49 | 71 | 36 | -22 | ||
| - | Colorado Rapids | 34 | 8 | 7 | 19 | 36 | 63 | 31 | -27 | ||
| - | San Jose Earthquakes | 34 | 4 | 9 | 21 | 49 | 71 | 21 | -22 |